Described herein is a method detecting a plurality of upper respiratory tract sub-regions automatically. Volume of interest (VOI) is identified based on the extraction of certain features, such as regional properties and shape-based features. The complete airway volume from a patient's data is identified by observing the area and eccentricity profiles of the certain volume/organ in the skull. Maxillary sinus area and eccentricity profile in the sagittal view is chosen in the present subject matter for level 1 VOI identification. Once a level 1VOI is identified, the other sub-regions existing in the same VOI are further identified as individual level 2 VOL Level 3 VOI is extracted based on the shape and geometric features of the organ. The extracted level 3 VOI is considered as the active contour that is followed by the initialized contour for the accurate segmentation of upper airway sub-regions.
