Wan Sung Choi,Eun Mi Hwang,Jae Yong Park,Gyeong Jae Cho,Young Hee Kim,So Yun Park
申请号：
US13980876
公开号：
US20140017203A1
申请日:
2012.01.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a recombinant adenovirus expressing an αA-crystallin gene, and gene therapy for retinal vascular disease using the recombinant adenovirus. Gene therapy using the recombinant adenovirus comprising an αA-crystallin gene of the present invention increases the expression level of the αA-crystallin gene in the damaged retinal pericytes to suppress pericyte loss and death, retinal vascular leakage, and leukocyte adhesion surrounding retinal vessels, thereby protecting the pericytes. Therefore, it can be used for the prevention and treatment of various retinal vascular diseases including diabetic retinopathy.
