A composition for inhibiting the attachment of microbes to an animate or inanimate surface is disclosed. The composition includes a carrier and an effective amount of an anti-adherent agent. The anti-adherent agents include botanical agents such Soybean extract, Horse chestnut extract, Gypenoside, Resveratrol, Astragalus extract, Rhubarb rootextract, Allium cepaextract, Cassia seedextract, Ginkgo bilobaextract, and Silymarin, and combinations thereof. The efficacy of the botanical agents is microbe and surface dependent. Various delivery vehicles, including a wipe, may be used to deliver the composition to the surface.