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Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
专利权人:
MERCK PATENT GMBH
发明人:
Valeur, Eric,Lepifre, Franck,Roche, Didier,Carniato, Denis,Christmann-Franck, Serge,Schmidlin, Fabien
申请号:
AU2009287118
公开号:
AU2009287118B9
申请日:
2009.08.05
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
The present invention relates to fused pyrrolidino-cyclopropane derivatives according to Formulae (I) to (II), as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-β-HSD-1 ) and the use of such compounds for the treatment and/or prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis/ cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
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来源网址:
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