Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors

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专利权人:

MERCK PATENT GMBH

发明人:

Valeur, Eric,Lepifre, Franck,Roche, Didier,Carniato, Denis,Christmann-Franck, Serge,Schmidlin, Fabien

申请号：

AU2009287118

公开号：

AU2009287118B9

申请日:

2009.08.05

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The present invention relates to fused pyrrolidino-cyclopropane derivatives according to Formulae (I) to (II), as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-β-HSD-1 ) and the use of such compounds for the treatment and/or prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis/ cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.

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