Quinazoline based EGFR inhibitors containing a zinc binding moiety

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专利权人:

Changgeng Qian

发明人:

Changgeng Qian,Xiong Cai,Stephen Gould,Haixiao Zhai

申请号：

US11852604

公开号：

US08604044B2

申请日:

2007.09.10

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to quinazoline containing zinc-binding moiety based derivatives of Formula (IV) below.These compounds have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and are useful in the treatment of EGFR-TK related diseases and disorders such as cancer. These compounds may further act as HDAC inhibitors.

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