HYDRATED CRYSTALLINE FORMS OF N-[3-FLUORO-4-({6-(METHYLOXY)-7-[(3-MORPHOLIN-4-YLPROPYL)OXY]-QUINOLIN-4-YL}OXY)PHENYL]-N-(4-FLUOROPHENYL)CYCLOPROPANE-1,1-DICARBOXAMIDE

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专利权人:

EXELIXIS; INC

发明人:

CANNON, HILARY,KANG, FEIRONG,VOGT, FREDERICK, G.

申请号：

SG2012067732

公开号：

SG184040A1

申请日:

2011.03.11

申请国别(地区):

SG

年份:

2012

代理人:

摘要：

This invention relates crystalline hydrates of N-[3-fluoro-4-({6-(methyloxy)-7-[(3- morpholin-4-ylpropyl)oxy]quinolin-4-yl }oxy)phenyl]-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, Compound (I). The invention provides methods for treatment of cancer by exploiting the modulation of protein kinase activity. The invention also provides pharmaceutical compositions containing a crystalline hydrate of Compound (I) and a pharmaceutically acceptable excipient.

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