Actogenix NV;The USA as Represented by The Secretary, National Institutes of Health
发明人:
Durum, Scott K.,Steidler, Lothar,Hanson, Miranda L.
申请号：
AU2011268146
公开号：
AU2011268146A1
申请日:
2011.06.17
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention provides methods and compositions for treating inflammatory bowel disease, including ulcerative colitis and Crohn's Disease, and other related conditions, by locally administering to the intestinal mucosa of a subject having inflammatory bowel disease a therapeutically effective amount of IL-27 or a therapeutic variant or fragment thereof. The invention further provides a method to treat inflammatory bowel disease comprising administering to the subject a recombinant microorganism capable of producing a therapeutically effective amount of IL-27 or a variant or fragment thereof in situ in the intestinal mucosa.
