The present invention is related to a nucleic acid molecule comprising a double-stranded structure, wherein the double-stranded structure is formed by a first strand and a second strand, wherein the first strand consist of the following nucleotide sequence 5 acGaGcUgGaCcAcUgGuCdTsdT 3, and the second strand consists of the following nucleotide sequence 5 GAcCaGuGgUcCaGcUcGudTsdT 3, wherein a minor nucleotide indicates that the nucleotide is 2-F modified and an underlined nucleotide indicates that the nucleotide is 2-0-methyl modified and wherein dTsdT indicates that at the 3 end a dinucleotide is attached consisting of two dT nucletoides, wherein said two dTs are covalently linked through a phosphorothioate bond.
