The U.S.A.; as represented by the Secretary; Department of Health and Human Services
发明人:
Claire Y. H. Kinney
申请号：
US16315897
公开号：
US20190298818A1
申请日:
2017.07.06
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Chimeric flaviviruses that include non-coding regions, non-structural proteins, a capsid (C) protein and a portion of a premembrane (prM) signal sequence from West Nile virus (WNV), and a portion of a prM signal sequence, a prM protein and an E protein from Zika virus (VIKV) are described. Also described are compositions and methods for eliciting an immune response in a subject, such as an immune response directed against ZIKV. Diagnostic assays that utilize chimeric West Nile/Zika viruses are further described.
