Scott A. Guelcher,Jerald E. Dumas,Edna Margarita Prieto,Katarzyna Zienkiewicz
申请号：
US13280299
公开号：
US20150283182A1
申请日:
2011.10.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Embodiments of the present inventions comprise composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. Certain embodiments further comprise a growth factor that can be provided in powder form. Growth factors may be bone morphogenic proteins, such as rhBMP-2. A porous composite comprises a plurality of bone particles, polyurethanes with which the bone particles are combined, and at least one growth factor. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.
