Nadine Dejneka;Ottrina S. Bond;Naveed Shams;Phillip Frost
发明人:
Phillip Frost,Nadine Dejneka,Ottrina S. Bond,Naveed Shams
申请号：
US12631078
公开号：
US08470792B2
申请日:
2009.12.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed herein are siRNA compositions and methods useful for inhibiting expression of vascular endothelial growth factor (VEGF) isoforms. Such compositions and methods further involve siRNA capable of selectively targeting angiogenic VEGF isoforms while selectively sparing anti-angiogenic isoforms. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering small interfering RNAs as disclosed.
