PROCEDE POUR AMELIORER L'EFFICACITE DE L'ADMINISTRATION AU SYSTEME NERVEUX CENTRAL D'UN GENE AAV PAR VOIE SYSTEMIQUE

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专利权人:

UNIVERSITY OF MASSACHUSETTS

发明人:

ESTEVES, MIGUEL SENA,BATISTA, ANA RITA,CHOUDHURY, SOURAV ROY

申请号：

CA3011939

公开号：

CA3011939A1

申请日:

2017.02.02

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The disclosure relates, in some aspects, to compositions and methods for enhanced delivery of a transgene to the central nervous system (CNS) of a subject. In some embodiments, the transgene is delivered by recombinant AAV (rAAV). In some embodiments, the method of enhancing transgene delivery comprises administering a blood brain barrier (BBB)-crossing molecule (e.g., K16ApoE) and an rAAV comprising a transgene to a subject.

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