A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof； (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v)； and (c) an effective amount of one or more compounds of formula (I) wherein R is H, PO3- or . The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).本案提供一種醫藥給藥系統，其包含(a)有效量之以下一或多者：杜亞拉明、其類似物、其衍生物、其前藥、其代謝物及/或其鹽；(b)有效量之以下一或多者：(i)吡哆醇、(ii)其類似物、(iii)其衍生物、(iv)其前藥、(v)其代謝物，及(vi)(i)-(v)中任一者之鹽；以及(c)有效量之一或多種式(I)化合物其中R為H、PO3-或。該系統相對於現行Diclectin®/Diclegis®調配物展現改良之藥物動力學概況，且適用於例如減輕噁心及嘔吐症狀，例如適用於減輕妊娠期之噁心及嘔吐(NVP)症狀。
