Compounds, compositions, kits, and methods for treating acne and other skin conditions by oral or topical administration of 19-nor containing vitamin D analogs with or without retinoids农业专利-农业学术服务平台

发明人:: クラジェットデイム、マーガレット,デルーカ、ヘクター、エフ．,ニーヴズ、ニルカ、ジェー．,プラム、ローリ、エー．,カイザー、メアリー、イー．,バリッキ、ラファル,デルーカ、ヘクター、エフ.,ニーヴズ、ニルカ、ジェー.,プラム、ローリ、エー.,カイザー、メアリー、イー.

摘要：: Topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin D analogs as active pharmaceutical ingredients include 19-nor-26,27-dimethylene-20(S)-2-methylene-1±,25-dihydroxyvitamin D3, 2-methylene-1±,25-dihydroxy-(17E)-17(20)-dehydro-19-nor vitamin D3, 2-methylene-(20R,25S)-19,26-dinor-1±,25-dihydroxyvitamin D3, 2-methylene-23,23-difluoro-1±-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1±-hydroxy-19-nor-bishomopregnancalciferol, (2-(3'hydroxypropyl-1',2'-idene)-19,23,24-trinor-(20S)-1±-hydroxyvitamin D3, a stereoisomer thereof, a prodrug thereof in oral compositions, a salt thereof, and/or a solute thereof.