PROBLEM TO BE SOLVED: To provide a tablet having excellent tablet physical properties and a small variation in hardness and disintegration, in a tablet containing loxoprofen (salt) and acetaminophen and to provide a method for producing the same.SOLUTION: There is provided a tablet which has a medicine layer containing the following components (A) and (B), wherein the mass ratio of the component (B) to the component (A) is 4.75 to 10. There is provided a method for producing a tablet which comprises a step of subjecting a drug-containing powder, which contains the following components (A) and (B) and has a mass ratio of component (B) to the component (A) of 4.75 to 10, to tableting and molding to form a medicine layer. Component (A): at least one selected from loxoprofen and its salt and component (B): acetaminophen.SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】ロキソプロフェン(塩)とアセトアミノフェンとを含有する錠剤において、錠剤物性に優れ、硬度や崩壊性のばらつきが小さい錠剤及びその製造方法の提供。【解決手段】本発明の錠剤は、下記(A)成分及び(B)成分を含む薬物層を有し、(B)成分/(A)成分で表される質量比が4.75~10である。本発明の錠剤の製造方法は、下記(A)成分及び(B)成分を含み、(B)成分/(A)成分で表される質量比が4.75~10である薬物含有粉体を打錠成形して薬物層を形成する工程を有する。 (A)成分:ロキソプロフェン及びその塩より選ばれる少なくとも1種 (B)成分:アセトアミノフェン【選択図】なし
