Hyunah Choo,Sun Joon Min,Seon Hee Seo,Jee Yeon Kim,Yoo Ran Ki,Min Joo Kim,Sora Kim,Youngjae Kim
申请号：
US14038324
公开号：
US09260448B2
申请日:
2013.09.26
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed are thienopyrimidinone derivatives as antagonists that act on metabotropic glutamate receptor subtype 1. The thienopyrimidinone derivatives show pharmacological activity against metabotropic glutamate receptor-related diseases, including pain, such as neuropathic pain and migraine, psychiatric diseases, such as anxiety disorder and schizophrenia, urinary incontinence, and neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Also disclosed are methods for preparing the thienopyrimidinone derivatives, and pharmaceutical compositions containing the thienopyrimidinone derivatives as active ingredients.
