Joseph R. Leventhal,James M. Mathew,Lorenzo Gallon,M. Javeed Ansari
申请号：
US14820795
公开号：
US09994817B2
申请日:
2015.08.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed are methods for isolating, cultivating, and/or cells including regulatory T cells (Tregs). The methods typically include cultivating cells including Tregs in a culture media comprising a ligand for programmed cell death receptor (PD-1) conjugated to a solid support. Suitable ligands may include PD-L1 and suitable solid supports may include magnetic or paramagnetic beads where the methods further include removing the PD-L1/bead conjugates after the Tregs have been isolated, cultured, and/or expanded.
