The present invention relates to use of Ludwigia octovalvis extract in manufacturing a composition for enhancing memory function and mitigating neurodegeneration. The present invention provides a composition for enhancing memory function and mitigating neurodegeneration, comprising an effective amount of Ludwigia octovalvis extract.本發明係關於水丁香(Ludwigia octovalvis)萃取物於製備增強記憶功能及延緩神經退化之組合物之用途,該組合物可為醫藥組合物或食品組合物。本發明提供一種增強記憶功能及延緩神經退化之組合物,其包含有效量之水丁香(Ludwigia octovalvis)萃取物。