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Carboline compounds useful in the treatment of neurodegenerative diseases
专利权人:
Alzprotect;Université de Lille 2 Droit et Santé;INSERM - Institut National de la Santé et de la Recherche Médicale
发明人:
MELNYK, Patricia,CARATO, Pascal,BURLET, Stéphane,NGUYEN, Emilie,VERWAERDE, Philippe,SERGEANT, Nicolas,ESTRELLA, Cécilia
申请号:
ES14733220
公开号:
ES2676698T3
申请日:
2014.06.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound according to formula (A) ** Formula ** or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, wherein X and Y are different from each other and are selected from: CH2 and ** Formula ** in which - nym are independently selected between 2 and 3; - R2 and R3 are independently selected from each other from the groups consisting of: - linear or branched (C1-C12) alkyl; linear or branched (C2-C12) alkenyl; linear or branched (C2-C12) alkynyl; said alkyl group, alkenyl group or alkynyl group may be substituted with at least one substituent selected from halogen, cycloalkyl, hydroxyl, alkoxy, amino, acylamino, aroylamino, heteroaroylamino and carboxy groups; - heteroaroylamino; - heterocycloalkyl (C2-C6) comprising in the cycle an oxygen atom and / or a nitrogen atom; - benzyl optionally substituted with an alkyl group, halogen, an ether group and / or an amino group; or R2 and R3 together with the nitrogen atom that carries them a saturated or unsaturated (C2-C7) heterocycle; R4 is selected from F, Cl, H, O-CH3, and -CH3; R5 is selected from H, CH3 and a phenyl group; with the condition that R5 is H if X is not CH2.Un compuesto de acuerdo con formula (A)**Fórmula** o una sal, solvato, clatrato, hidrato o polimorfo farmacéuticamente aceptable del mismo, en la que X e Y son diferentes entre sí y se seleccionan entre: CH2 y**Fórmula** en la que - n y m se seleccionan de forma independiente entre 2 y 3; - R2 y R3 se seleccionan de forma independiente entre sí entre los grupos que consisten en: - alquilo (C1-C12) lineal o ramificado; alquenilo (C2-C12) lineal o ramificado; alquinilo (C2-C12) lineal o ramificado; dicho grupo alquilo, grupo alquenilo o grupo alquinilo puede estar sustituido con al menos un sustituyente seleccionado entre grupos halógeno, cicloalquilo, hidroxilo, alcoxi, amino, acilamino, aroilamino, heteroaroilamino y carboxi; - heteroaroilamino; - heterocicloalquilo (C2-C6) que comprende en el ciclo un átomo de oxígen
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