The present disclosure is directed to individual Aß peptide immunogen constructs, peptide compositions comprising these Aß peptide immunogen constructs and mixtures thereof, pharmaceutical compositions including vaccine formulations comprising these A? peptide immunogen constructs, with the individual A? peptide immunogen constructs having the N-terminus of the A? peptide as the B cell (B) epitopes linked through spacer residue(s) to heterologous T helper cell (Th) epitopes derived from pathogen proteins that act together to stimulate the generation of highly specific antibodies directed against the N-terminus of the Aß peptide offering protective immune responses to patients at risk for, or with, Alzheimers Disease.
