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POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME
专利权人:
发明人:
Young Ho SUNG,Greg TROIANO,Hong WANG,Maria FIGUEIREDO,Michael H. LAM,Caroline MCGREGOR
申请号:
US15126894
公开号:
US20170087135A1
申请日:
2015.03.12
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Described herein are polymeric nanoparticles that comprise 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]-triazolo-[3,4-fJ[1,6]-naphthyridin-3-one (Compound A), or a pharmaceutically acceptable salt thereof, and methods of making and using such nanoparticles. The nanoparticle comprises about 50 to about 99.8 weight percent of a diblock poly(lactic) acid-poly(ethylene)glycol copolymer or a diblock poly(lactic acid-co-glycolic acid)-poly(ethylene)glycol copolymer, wherein the total amount of poly(ethylene)glycol in the nanoparticle is about 10 to about 30 weight percent poly(ethylene)glycol and about 0.2 to about 30 weight percent of Compound A.
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