LUNDSTEDT, TORBJORN,SEIFERT, ELISABETH,LEK, PER,BOMAN, ARNE
申请号：
CA2669162
公开号：
CA2669162C
申请日:
2007.11.09
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
There are described compounds of formula (I) in which R3to R8 are independently selected from hydrogen, halogen, trihaloalkyl, alkyl having 1, 2, 3, 4 or 5 carbon atoms, electron donor groups selected from alkoxy having 1, 2, 3, 4 or 5 carbon atoms, trihaloalkoxy, hydroxy or amino, electron acceptor groups selected from cyano, sulphonic, nitro, or amide； R1 is an optionally substituted phenyl, benzyl or cyclohexyl group； R2 is selected from amino, substituted amino or guanidino groups, Z is a saturated or unsaturated C1-5 hydrocarbon chain, and salts thereof. A process for their preparation and compositions containing them are also described. The compounds are either agonists or antagonists of a specific adenosine receptor or a number of adenosine receptors and have usefulness for the treatment of inflammation, arthritic conditions, rheumatoid arthritis, osteoarthritis, mental disorders, or for inducing central nerve regeneration.
