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NOUVEAUX AMIDES AGISSANT SUR LES RECEPTEURS D'ADENOSINE
专利权人:
ACURE PHARMA AB
发明人:
LUNDSTEDT, TORBJORN,SEIFERT, ELISABETH,LEK, PER,BOMAN, ARNE
申请号:
CA2669162
公开号:
CA2669162C
申请日:
2007.11.09
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
There are described compounds of formula (I) in which R3to R8 are independently selected from hydrogen, halogen, trihaloalkyl, alkyl having 1, 2, 3, 4 or 5 carbon atoms, electron donor groups selected from alkoxy having 1, 2, 3, 4 or 5 carbon atoms, trihaloalkoxy, hydroxy or amino, electron acceptor groups selected from cyano, sulphonic, nitro, or amide; R1 is an optionally substituted phenyl, benzyl or cyclohexyl group; R2 is selected from amino, substituted amino or guanidino groups, Z is a saturated or unsaturated C1-5 hydrocarbon chain, and salts thereof. A process for their preparation and compositions containing them are also described. The compounds are either agonists or antagonists of a specific adenosine receptor or a number of adenosine receptors and have usefulness for the treatment of inflammation, arthritic conditions, rheumatoid arthritis, osteoarthritis, mental disorders, or for inducing central nerve regeneration.
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