Pablo E. Vivas-Mejia,Jeyshka M. Reyes Gonzalez,Anil K. Sood
申请号：
US14681875
公开号：
US09895312B2
申请日:
2015.04.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention discloses c-MYC-siRNA formulation as a potential therapeutic target for cisplatin-resistant ovarian cancer. It is disclosed targeting c-MYC with small interfering RNA (siRNA) in the cisplatin-resistant ovarian cancer cell line inducing a significant cell growth arrest and inhibition of cell proliferation. Apoptosis and arrest of cell cycle progression were also observed after c-MYC-siRNA-based silencing of c-MYC. Furthermore, delivering nanoliposomal c-MYC-siRNA, decreased tumor weight and number of tumor nodules compared with a liposomal-negative control siRNA.
