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DÉRIVÉS DE CARBAMOYLPYRIDONE POLYCYCLIQUE DOTÉS D'UNE ACTIVITÉ INHIBITRICE DE L'INTÉGRASE DU VIH
专利权人:
VIIV Healthcare Company;Shionogi & Co., Ltd
发明人:
申请号:
EP17195276.5
公开号:
EP3284519A8
申请日:
2006.04.28
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention is to provide a novel compound (I-1) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof.whereinA ring is substituted ring of (a), (b) or (c)wherein Z is O or NR19,R19 is hydrogen, C1-10alkyl, C2-8alkenyl, C1-10alkylcarbonyl or C1-10alkylsulfonyl, and the other substituents on the A ring form a ring;R14 and RX are hydrogen;a broken line represents the presence or absence of a bond, provided that when the broken line represents the presence of a bond, RX is not present;R1 is hydrogen or C1-10alkyl;X is C1-6alkylene;R2 is phenyl or phenyl substituted with at least halogen;R3 is hydrogen, halogen, hydroxy, C1-10alkyl, C2-8alkenyl, C1-10alkoxy, C2-8alkenyloxy or amino;or a pharmaceutically acceptable salt, or solvate thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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