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Urea derivatives or pharmacologically acceptable salts thereof useful as agonists of the formylated peptide receptor 1 (FRPL-1)
专利权人:
Ltd.;Kyorin Pharmaceutical Co.
发明人:
TAKAHASHI, Hiroyasu,SAITO, Yoshifumi,TSUDA, Kosuke,SHIBASAKI, Mitsuhito,OHATA, Kohei
申请号:
ES14865553
公开号:
ES2659156T3
申请日:
2014.11.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound represented by the general formula (I) or a pharmacologically acceptable salt thereof or a solvate or a hydrate thereof: ** Formula ** wherein, in the formula (I), Ar1 is a phenyl group that optionally has a substituent or substituents, a 5-membered aromatic heterocyclic group that optionally has a substituent or substituents, a 6-membered aromatic heterocyclic group that optionally has a substituent or substituents, or a bicyclic aromatic heterocyclic group having 8 or 9 atoms and optionally having a substituent or substituents; Ar2 is a phenyl group that optionally has a substituent or substituents (with the exception of a phenyl group substituted only with a halogen atom), a 5-membered aromatic heterocyclic group that optionally has a substituent or substituents, an aromatic heterocyclic group of 6 members that optionally have a substituent or substituents or a bicyclic aromatic heterocyclic group having 8 or 9 atoms and optionally having a substituent or substituents; X is a group selected from the group consisting of the following a), b) and c), a) an oxygen atom or a sulfur atom, b) NR4, and c) NOR4, where, when X is b) oc ), R4 is a hydrogen atom, a phenyl group that optionally has a substituent or substituents, a heterocyclic group that optionally has a substituent or substituents or a C1 to C6 alkyl group that optionally has a substituent or substituents; R1 is a hydrogen atom, a hydroxy group, a C1 to C6 alkoxy group that optionally has a substituent or substituents or a C1 to C6 alkyl group that optionally has a substituent or substituents; R2 and R3 are independently from each other a hydrogen atom or a C1 to C6 alkyl group that optionally has a substituent or substituents or together form a C2 to C6 alkylene group; and each carbon atom marked with an asterisk is an asymmetric carbon atom]. wherein the expression "which optionally has a substituent or substituents" means optionally substituted with one or more substituents selected from the gr
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