Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
发明人:
Yanhe Lue,Ronald S. Swerdloff,Peter Yiwen Liu,Krista Erkkila,Christina Wang
申请号：
US14508763
公开号：
US20150258149A1
申请日:
2014.10.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention pertains to the discovery that stem cells (e.g., bone marrow stem cells) transplanted directly into a testicular environment are transdifferentiated into bona fide Sertoli cells, and/or Leydig cells, and/or and germ cells. This provides a mechanism for the treatment of male infertility and/or testosterone deficiency. Thus, in one embodiment, this invention provides a method of treating infertility or testosterone deficiency in a male mammal. The method typically involves implanting stem cells into the testes of the mammal whereby the stem cells differentiate into germ cells and/or Sertoli cells and/or Leydig cells thereby reducing infertility and/or testosterone deficiency.
