Alan Edward ROWAN,Petrus Johannes GEUTJES,Wouter F.j. FEITZ,Egbert OOSTERWIJK,Zaskia Hillet EKSTEEN AKEROYD,Christopher WILSON
申请号：
MX2016000612
公开号：
MX2016000612A
申请日:
2014.07.16
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
The invention relates to a process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process comprises the steps of: i) copolymerizing - a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and - a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is :500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula A-L-B, wherein the linking group and group A are chosen to react and form a first coupling and the cell adhesion factor and group B are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornadiene-based-azide couplings, vinylsulphone-thiol coupling, maleimide-thiol coupling, methyl methacrylate-thiol coupling, ether coupling, thioether coupling, biotin- strepavidin coupling, amine-carboxylic acid resulting in amides linkages, alcohol- carboxylic acid coupling resulting in esters linkages and NHS-Ester (N- Hydroxysuccinimide ester)-amine coupling and wherein group L is a linear chain segment having 10-60 bonds between atoms selected from C, N, O and S in the main chain.La invención se refiere a un procedimiento para preparar un copoliisocianopéptido funcionalizado con oligo (alquilenglicol), comprendiendo el procedimiento las etapas de: i) copolimerizar - un primer comonómero de un isocianopéptido funcionalizado con oligo (alquilenglicol) injertado con un grupo enlazante y - un segundo monómero de un isocianopéptido funcionalizado con oligo (alquilenglicol) sin injertar, en donde la proporción molar entre el primer comonómero y el segundo comonómero esde 1:500 y 1:30 y ii) añadi
