Mark De Boer,Carsten Linnemann,Antonius Nicolaas Maria Schumacher,Riccardo Mezzadra
申请号：
US15518358
公开号：
US20170354681A1
申请日:
2015.10.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides compositions and methods for immunotherapy in human. The invention includes a B cell receptor like complex expressed in T cells and comprising an extracellular antigen recognition domain, a trans-membrane domain, a CD79αβ heterodimer, and a signaling region that controls T cell activation. The extracellular antigen recognition domain and trans-membrane are derived from the same human or humanized B cell receptor and form a single unit in the complex. The signaling region comprises a T cell signaling domain in combination with a co-stimulatory signaling domain. The signaling region is fused to the CD79αβ heterodimer. Furthermore, the B cell receptor like complex of the present invention can use a targeting molecule as a bridge between cytotoxic T cells and targeted cells.
