Heteroaromatic compounds of Formula I:are HIV reverse transcriptase inhibitors, wherein R1, R2, R3, R4and R5are defined herein. The compounds of Formula I and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.本發明提供式I雜芳族化合物:其為HIV反轉錄酶抑制劑,其中R1、R2、R3、R4及R5如本文所定義。該等式I化合物及其醫藥學上可接受之鹽適用於抑制HIV反轉錄酶,預防及治療HIV感染及預防、延緩AIDS之發作或惡化及治療AIDS。該等化合物及其鹽可用作醫藥組合物中之成分,視情況與其他抗病毒劑、免疫調節劑、抗生素或疫苗組合。
