The present embodiments provide apparatus and methods for facilitating endoscopic resection of tissue. In one embodiment, the apparatus comprises a first tube having proximal and distal regions, and a working lumen disposed within at least a portion of the distal region. A second tube is disposed circumferentially around at least a portion of the distal region of the first tube. A wire has a distal end that is securely attached to a distal region of the second tube. In use, rotation of the second tube relative to the first tube causes the wire to pass circumferentially over a distal face of the first tube to incise tissue disposed within the working lumen of the first tube.
