A compound of formula Ib: and pharmaceutically acceptable enantiomers, salts or solvates thereof, in which: R2 and R3 are the same or different and represent a hydrogen atom or a group selected from hydroxyl, amino, halo, nitro, cyano, acid carboxylic, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, hydroxyalkyl, alkoxy, C1-C8 acyl, haloalkyl, preferably R2 and R3 represent hydrogen, alkyl, cycloalkyl or haloalkyl, more preferably hydrogen, methyl or CF3； Z1 represents a hydrogen atom or a group selected from halo, hydroxyl, nitro, amino, amido, carbamate, carbamide, sulfonamide, alkoxy, alkyl, haloalkyl, alkenyl, alkynyl, aryl, heteroaryl, 4-amino-cyclobut-3-ene -1,2- dione, 3-hydroxythiophene-2-yl-methanone, or form with Z2 an aryl ring, a heteroaryl ring, a cycloalkyl ring or a heterocyclyl, optionally substituted with one or more groups selected from oxo, halo, hydroxyl, nitro, amino, alkoxy, alkyl, haloalkyl, alkenyl, alkynyl, aryl, heteroaryl； preferably Z1 represents H, F, Cl, Br, NO2, NH2, NMe2, OH, OMe, CH3 or CF3； Z2 represents a hydrogen atom or a group selected from halo, hydroxyl, nitro, amino, amido, carbamate, carbamide, sulfonamide, alkoxy, alkyl, haloalkyl, alkenyl, alkynyl, aryl, heteroaryl, 4-amino-cyclobut-3-ene -1,2-dione, 3-hydroxythiophene-2-yl-methanone, or form with Z1 or Z3 an aryl ring, a heteroaryl ring, a cycloalkyl ring or a heterocyclyl, optionally substituted with one or more groups selected from oxo, halo, hydroxy, nitro, amino, alkoxy, alkyl, haloalkyl, alkenyl, alkynyl, aryl, heteroaryl； preferably Z2 represents H, F, Cl, Br, NO2, NH2, NMe2, OH, OMe, CH3 or CF3； Z3 represents a hydrogen atom or a group selected from halo, hydroxyl, nitro, amino, amido, carbamate, carbamide, sulfonamide, alkoxy, alkyl, haloalkyl, alkenyl, alkynyl, aryl, heteroaryl, 4-amino-cyclobut-3-ene -1,2- dione, 3-hydroxythiophene-2-yl-methanone, or form with Z2 or Z4 an aryl ring, a heteroaryl ring, a cycloalkyl ring or a heterocyclyl, optionally substi
