LANCE A. LIOTTA,ALESSANDRA LUCHINI KUNKEL,BENJAMIN LEPENE,FATAH KASHANCHI
申请号：
US16430300
公开号：
US20190365921A1
申请日:
2019.06.03
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A system and method configured to achieve hydrogel particle treatment for the reduction of metastatic burden in an immunocompetent syngeneic mouse model is described. The system seeks to achieve methodic optimization for the extraction and purification of extracellular vesicles (EVs) from cultured cells as well as from fresh breast cancer interstitium. Similarly, the system provides for lymph node remodeling by human breast cancer EVs in a humanized mouse model. Hydrogel particles are employed to convey cytokine releasing and EV-displaying treatment to afflicted bodies. The process and system is envisioned to be applied to other diseases and cancers, and is not therefore limited to metastatic cancers
