The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.本發明係關於與NR1H4受體(FXR)結合且用作FXR之促效劑的化合物。本發明進一步關於該等化合物用於製備經由該等化合物結合該核受體來治療疾病及/或病狀之藥劑的用途,以及該等化合物之合成方法。