A wearable medical treatment system for medical treatment of a patient is described. An example of the system includes sensors configured to be externally positioned on the patient, the sensors including cardiac sensing electrodes configured to provide a signal indicative of the patients cardiac information, defibrillation electrodes configured to be externally positioned on the patient and to deliver a defibrillation shock, a cuff configured to contract about a patients limb, and a controller communicatively coupled to the sensors, the defibrillation electrodes, and the cuff. The controller is configured to receive the signal indicative of the patients cardiac information, determine the patients cardiac information, control delivery of the defibrillation shock by the defibrillation electrodes based at least in part on the patients cardiac information, and control contraction of the cuff based according to a remote ischemic conditioning (RIC) protocol and based at least in part on the patients cardiac information.
