Oxidant-promoting compositions that increase antioxidant defense potential in a subject is disclosed comprising Asparagus officinalis, Withania somnifera, Acromus calamus, Nardostachys jatamansi, Quercus infectoria, Boerhaavia diffusa, Medicago sativa. The antioxidant-promoting composition of the invention safety induces cellular antioxidant potential to achieve an overall net decrease in oxidative stress without the undesirable side effects associated with an individual component of the antioxidant-promoting composition.