An internal lumen disinfection device has a case, a power source, a UV lamp, a plurality of light transmitting connectors and at least one light transmitting tube. The case has a lid or cover and an elongated base configured to hold one or more surgical endoscopes in a disinfecting portion and a power and UV lamp housing portion adjacent the disinfecting portion. A battery or electrical power source is in the housing portion. The UV lamp is in the housing portion connected to and powered by the power source. The case has a divider wall with openings for passing UV light. The plurality of light transmitting connectors are each affixed to the divider wall at an opening. At least one light transmitting tube, preferably a plurality of light transmitting tubes are used to disinfect lumens of endoscopes.