Jan zur Megede,Susan Barnett,Ying Lian,Susan Engelbrecht,Estrelita Janse van Rensburg,Thomas J. Scriba
申请号：
US11724050
公开号：
US08133494B2
申请日:
2007.03.13
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to polynucleotides encoding modified immunogenic HIV-1 South African subtype C Env polypeptides. The modifications to the Env polypeptides include deletions of V1, V2 and the stem region. The expression cassettes may be used, for example, to express the encoded polypeptide. A recombinant expression system for use in a selected host cell comprising an expression cassette encoding for the modified HIV-1 Env polypeptide is also described.
