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Methods for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity
专利权人:
Takeshi Fukuhara;Masaaki Suzuki;Masatoshi Hagiwara;Takamitsu Hosoya
发明人:
Masatoshi Hagiwara,Takeshi Fukuhara,Masaaki Suzuki,Takamitsu Hosoya
申请号:
US12494102
公开号:
US08338362B2
申请日:
2009.06.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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