JENKINS THOMAS E,HUSFELD CRAIG O,SEROOGY JULIE D,WRAY JONATHAN W
申请号：
IN2340/CHENP/2012
公开号：
IN2012CN02340A
申请日:
2012.03.14
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
A method of providing a patient with controlled release of ketone-containing opioid using a prodrug capable upon enzymatic activation and intramolecular cyclization of releasing the ketone-containing opioid is disclosed. The disclosure also provides such prodrug compounds and pharmaceutical compositions comprising such compounds. Such pharmaceutical compositions can optionally include an enzyme inhibitor that interacts with the enzyme(s) to mediate the enzymatically-controlled release of the ketone-containing opioid from the prodrug so as to modify enzymatic cleavage of the prodrug. Also included are methods to use such compounds and pharmaceutical compositions.
