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Oxazole kinase inhibitors
专利权人:
AB SCIENCE
发明人:
MOUSSY, ALAIN,BENJAHAD, ABDELLAH,MARTIN, JASON,CHEVENIER, EMMANUEL,PEZ, DIDIER,SANDRINELLI, FRANCK,PICOUL, WILLY
申请号:
ES11702802
公开号:
ES2539170T3
申请日:
2011.01.12
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of formula I: ** Formula ** in which the substituents A, Q, X, R1, R2, R3, V and W in formula I are defined as follows: A is one of the following: i ) N (R4) (CH2) n where n is 0 <;n <;3 ii) O (CH2) n where n is 0 <;n <;3 iii) S (CH2) n where n is 0 <;n <;3 iv) ( CH2) n where n is 0 <;= n <;4 v) C (O) (CH2) n where n is 0 <;n <;3 vi) C (R4)>; = C (R5) vii) C≡C (R5) R4 and R5 each independently are hydrogen, C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 hydroxyalkyl, C1-4 alkylamino; X is CH or N; V is O; Q is selected from: ~ i) an alkyl group1, or ii) an aryl1 group, or iii) a heteroaryl1 group; an alkyl group 1 is defined as a linear, branched or cycloalkyl alkyl group containing from 1 to 10 carbon atoms and optionally substituted with one or more heteroatoms selected from halogen, oxygen and nitrogen; trifluoromethyl, carboxyl, cyano, nitro, formyl; CO-R, COO-R, CONR-R ', SO2-R, and SO2NR-R' in which R and R 'are a linear or branched alkyl group containing 1 to 10 carbon atoms and optionally substituted with at minus a heteroatom, selected from a halogen, oxygen and nitrogen; or a cycloalkyl group; an aryl group 1 is defined as phenyl or a substituted variant thereof that carries any combination, at any position of the ring, of one or more substituents selected from halogen; - an alkyl group 1; - an aryl or heteroaryl group; a trifluoromethyl, O-alkyl, carboxyl, cyano, nitro, formyl, hydroxy, NH-alkyl, N (alkyl) (alkyl) and amino group; - NRCO-R 'or NRCOO-R' or NRCONR'-R "or NRSO2-R 'or NRSO2NR'-R" or CO-R or COO-R or CONR-R' or SO2- R or SO2NRR 'in which R, R 'and R "are each independently selected from hydrogen, an alkyl, aryl or heteroaryl group; a heteroaryl group1 is defined as a pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, thienyl, thiazolyl, imidazolyl, pyrazolyl, pyrrolyl, furanyl group , oxazolyl, isoxazolyl, triazolyl, tetrazolyl, indolyl, benzimidazole, benzoxazol, benzothi
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