NKT-CELL SUBSET FOR IN VIVO PERSISTENCE AND THERAPEUTIC ACTIVITY AND PROPAGATION OF SAME

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专利权人:

Baylor College of Medicine

发明人:

Leonid S. Metelitsa,Amy N. Courtney,Gengwen Tian

申请号：

US15135453

公开号：

US20160310532A1

申请日:

2016.04.21

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Embodiments of the disclosure include methods and compositions for producing NKT cells effective for immunotherapy and also methods and compositions for providing an effective amount of NKT cells to an individual in need of immunotherapy. In specific embodiments, the NKT cells are CD62L+ and have been exposed to one or more costimulatory agents to maintain CD62L expression. The NKT cells may be modified to incorporate a chimeric antigen receptor, in some cases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/