FELDMAN, DAVID LOUIS,LUFT, FRIEDRICH CAMERON,MUELLER, DOMINIK NICOLAS,WEBB, RANDY LEE
申请号：
ES05810560
公开号：
ES2384637T3
申请日:
2005.10.06
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Pharmaceutical composition comprising a renin inhibitor, or a pharmaceutically acceptable salt thereof, in combination with (i) an ACE inhibitor, or a pharmaceutically acceptable salt thereof； or (ii) an angiotensin II receptor blocker, or a pharmaceutically acceptable salt thereof； and a pharmaceutically acceptable carrier； for use in the treatment of diastolic dysfunction or cardiac-diastolic insufficiency, in which the renin inhibitor is selected from the group consisting of RO 66-1132, RO 66-1168 and a compound of formula (III) in which R1 is halogen , C1-6 halogenoalkyl, C1-6 alkoxy-C1-6 alkyloxy or C1-6 alkoxy-C1-6 alkyl； R2 is halogen, C1-4 alkyl or C1-4 alkoxy； R3 and R4 are independently branched C3-6 alkyl； and R 5 is cycloalkyl, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 alkanoyloxy-C 1-6 alkyl, C 1-6 aminoalkyl, C 1-6 alkylamino-C 1-6 alkyl, C1-6 dialkylamino-C1-6 alkyl, C1-6 alkanoylamino-C1-6 alkyl, HO (O) C-C1-6 alkyl, C1-6 alkyl-O- (O) C-C1-6 alkyl, H2N- C (O) -C 1-6 alkyl, C 1-6 alkyl-HN-C (O) -C 1-6 alkyl or (C 1-6 alkyl) 2N-C (O) -C 1-6 alkyl； or in each case a pharmaceutically acceptable salt thereof, with the proviso that, when the composition comprises (ii) an angiotensin II receptor blocker or a pharmaceutically acceptable salt thereof, it does not comprise a neutral endopeptidase (NEP) inhibitor, or a pharmaceutically acceptable salt thereof.Composición farmacéutica que comprende un inhibidor de la renina, o una sal farmacéuticamente aceptable delmismo, en combinación con(i) un inhibidor de la ACE, o una sal farmacéuticamente aceptable del mismo； o(ii) un bloqueante de los receptores de angiotensina II, o una sal farmacéuticamente aceptable del mismo； y unportador farmacéuticamente aceptable； para su uso en el tratamiento de disfunción diastólica o insuficiencia cardiacadiastólica.en la que el inhibidor de la renina se selecciona del grupo que consiste en RO 66-1132, RO 66-1168 y un compuestode fórmula (III)en la que R1
