MARK E. DAVIS,JUNGYEON HWANG,TIANYI KE,JING-JOU LIM,THOMAS SCHLUEP
申请号：
IN4563/DELNP/2009
公开号：
IN273456B
申请日:
2009.07.13
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The tether comprises a self-cyclizing moiety, such as -S-CH2-CH2- CO-, -NR-CH2-CH2-NR-CO- and -S-CH2-CH2-NR-CO-. The present invention also relates to drug conjugates comprising cyclodextrin-based polymers.
