The present invention provides an anti-cancer oral formulation comprising 0.01 to 95 wt. %. of a biotransformed product of Calendulla officinalis flowers, said biotransformed product is cow urine macerated product and optionally, at least one pharmaceutically acceptable excipient. The formulation is in a form selected from the group consisting of a tablet, a capsule, a pill, a pastille, a lozenge, powder and liquid.