A jejunostomy feeding device includes an elongate flexible member extending from a proximal end to a distal end and including a feeding lumen extending therethrough. The device also includes a first balloon attached to a distal portion of the flexible member. In addition, the device includes a second balloon attached to the flexible member proximally of the first balloon, the second balloon including a groove extending about at least a portion of a circumference thereof to anchor the second balloon within target anchoring tissue upon inflation thereof, wherein the first balloon and the second balloon are separated by a first distance selected so that when the second balloon is positioned at a target site within a target body lumen, the second balloon anchors the first balloon within the target body lumen positioned so that the first balloon presses against an inner wall of the body lumen to seal an entry point at which the flexible member enters the body lumen.
