INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL);INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
发明人:
Aurora PUJOL ONOFRE,Stéphane FOURCADE
申请号：
US15957601
公开号：
US20190321322A1
申请日:
2018.04.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Therapeutic solutions for axonal degeneration include use of NRF2 activators in prevention and/or treatment of axonal degeneration. A method of prevention and/or treating axonal degeneration includes administering a therapeutically effective amount of a NRF2 activator selected from a GSK3 inhibitor or the compound of formula (I):wherein R1 and R2, which may be the same or different, independently represent H, a linear, branched wherein R1 and R2, which may be the same or different, independently represent a linear, branched or cyclic, saturated or unsaturated C1-6 alkyl radical, a pharmaceutical salt thereof or a metabolite or precursor of the dimethyl fumarate to a patient in need of the treatment.
