KIM, JI SOOK,金知淑,KIM, WON JEOUNG,金元政,JANG, WOOK,张旭,張旭,SONG, JI YOUNG,宋芝英,LEE, MOON SUB,李文燮,KIM, NAM DU,金南斗,SUH, KWEE HYUN,徐贵贤,徐貴賢
申请号：
TW104114467
公开号：
TW201623321A
申请日:
2015.05.06
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention relates to a novel bicyclic derivative that has an inhibitory activity against sodium-glucose linked transporters (SGLTs) present in the intestines and kidneys, or a pharmaceutically acceptable salt, isomer, hydrate or solvate thereof, and a pharmaceutical composition including the same as an active ingredient, which effectively inhibit the SGLT activity, and thus can be used as a therapeutic agent to treat diseases caused by hyperglycemia, such as diabetes including insulin-dependent diabetes (type I diabetes mellitus) and non-insulin-dependent diabetes (type II diabetes mellitus), diabetic complications, and obesity.本發明係有關於對存在於腸道及腎臟之鈉-葡萄糖共轉運體(sodium-glucose linked transporters，SGLTs)具有抑制活性之一新穎雙環衍生物，或其一藥學上可接受之鹽、異構物、水合物，或溶劑合物，及含有作為一活性成份之此者的一藥學組成物，其有效抑制SGLT活性，因此，可作為用以治療藉由高血糖造成的疾病之一治療劑，諸如，包括胰島素依賴性之糖尿病(第I型糖尿病)及非胰島素依賴性之糖尿病(第II型糖尿病)之糖尿病、糖尿病併發症，及肥胖症。
