Use of a growth hormone protein and polynucleotides encoding same comprising an amino terminal carboxy terminal peptide (CTP) of chorionic gonadotrophin and two carboxy terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing weight loss or body fat reduction methods of increasing insulin like growth factor (IGF 1) levels and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.
