КОЛКА Джерард Р. (US),КЛЕТЗИН Рольф Ф. (US),ТАНИС Стивен П. (US),ЛАРСЕН Скотт Д. (US)
申请号：
RU2012130011/15
公开号：
RU2012130011A
申请日:
2010.12.15
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method for treating or delaying the start of diabetes, comprising administering to the patient a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: each of R are independently selected from H, halo, aliphatic, and alkoxy, wherein the aliphatic or alkoxy group optionally substituted by 1 -3 halogens Rpredstavlyaet is H R is H, halo, hydroxy, or optionally substituted aliphatic group, -O-acyl, -O-aroyl, -O-heteroaroyl, -O (SO) NH, -O-CH ( R) OC (O) R, -O-CH (R) OP (O) (OR), -OP (O) (OR) wherein each R or c is independently optionally substituted Ci ^ alkyl, each R is independently Ci ^ alkyl Ctsikloalkil or phenyl, each of which is optionally substituted, iliRi Rvmeste form oxo R is H ikoltso A represents phenyl, pyridin-2-yl, pyridin-3-yl or pyridin-4-yl, each of which is substituted and Rgruppoy Rgruppoy ianaloga or GLP DPP4.2 inhibitor. A method according to claim 1, wherein R is H, methyl, methoxy, ethyl, ethoxy, -O-isopropyl, -CF, -OCHFili -OCF.3. A method according to any of claims 1 or 2, wherein R is H, alkyl, halo or alkoksi.4. A method according to claim 1, wherein ring A represents phenyl which is substituted Rgruppami r and in any chemically allowable position in A.5 ring. A method according to claim 1, in which Ring A is pyridin-2-yl or pyridin-3-yl, any of which is substituted Rgruppami r and in any chemically allowable position in ring A.6. A method according to claim 4, in which Ring A is phenyl and one of R or Rprisoedinen to the para- or meta-position of the ring A.7. A method according to claim 5, in which Ring A is pyridin-2-yl and one of R or to the 5 position Rprisoedinen koltsa.8. A method according to claim 5,
