Radiation - oxidative exposure treatment compositions comprise a mixture of micronutrient multivitamin and trace elements, a mixture of antioxidants and chemopreventative agents, and optionally a mixture of fatty acids. Micronutrient multivitamin and trace elements mixtures include vitamins A, Bp, Bl, B2, B3, B5, B6, B7, B9, B12, C, D, E and K inositol calcium, iodine, magnesium, zinc, selenium, copper, manganese, chromium, molybdenum, potassium, boron and vanadium. Mixtures of non¬ essential antioxidants and chemopreventative agents include bioflavins, alpha lipoic acid, N- acetyl-L-cysteine, lutein, lycopene, astaxanthin, plant sterols, isoflavones, garlic extract, which provides allicin green tea extract, cruciferous vegetable extract, fruit extracts, ginkgo biloba extract, coenzyme Q-10, and resveratrol. Fatty acid mixtures include eicosapentaenoic acid and docosahexaenoic acid. Methods of treatment of a subject exposed to a radiation source or an oxidative stress with the radiation - oxidative exposure treatment composition include the step of administering to the subject a daily dose of the radiation - oxidative exposure treatment composition such that the life shortening effects induced by the radiation source or the oxidative stress are ameliorated.Linvention concerne des compositions de traitement dune exposition au rayonnement - à un stress oxydant comprenant un mélange de multivitamines micronutriments et doligoéléments, un mélange dagents anti-oxydants et dagents de chimio-prévention et facultativement un mélange dacides gras. Des mélanges de multivitamines micronutriments et doligoéléments comprennent les vitamines A, Bp, B1, B2, B3, B5, B6, B7, B9, B12, C, D, E et K de linositol du calcium, de liode, du magnésium, du zinc, du sélénium, du cuivre, du manganèse, du chrome, du molybdène, du potassium, du bore et du vanadium. Des mélanges dagents anti-oxydants non essentiels et dagents de chimio-prévention comprennent des bioflavines, de lacide alpha-lip